- Jonny Lee Miller as Sherlock Holmes
- Lucy Liu as Joan Watson
- Aidan Quinn as Captain Tommy Gregson
- Jon Michael Hill as Detective Marcus Bell
- Richard Thomas as Mitch Barrett
- Rob McClure as Grant Huber
- Gordon Clapp as Deputy Chief Prosky
- Linda Powell as Congresswoman Salazar
- Suzy Jane Hunt as Susan
- Daniel Cosgrove as Len
- Bridget White as Laurie Barrett
- Myra Lucretia Taylor as Shelley
- Maechi Aharanwa as Waitress
- Owain Yeoman as Julius Kent
- The Edgar Winter Group - Frankenstein plays as Watson and Bell question a waitress in a diner frequented by Russell Cole.
- The Draxculas - Side by Side plays at episode end as Captain Gregson gives a speech congratulating the Major Cases unit on their unit award.
- "I'm better at the work I do because of you. But over the years the relative importance of those two values has flipped. I now value the work that we do, first and foremost, because I do it with you."
- ―Holmes to Watson
|Elementary Season Five Episodes|
|Folie a Deux • Worth Several Cities • Render, and Then Seize Her • Henny Penny the Sky Is Falling • To Catch a Predator Predator • Ill Tidings • Bang Bang Shoot Chute • How the Sausage Is Made • It Serves You Right to Suffer • Pick Your Poison • Be My Guest • Crowned Clown, Downtown Brown • Over a Barrel • Rekt in Real Life • Wrong Side of the Road • Fidelity • The Ballad of Lady Frances • Dead Man's Tale • High Heat • The Art of Sleights and Deception • Fly Into a Rage, Make a Bad Landing • Moving Targets • Scrambled • Hurt Me, Hurt You|
|Season One • Season Two • Season Three • Season Four • Season Five • Season Six • Season Seven|